CCL23 / Myeloid Progenitor Inhibitory Factor 1 Antibody
Product Sizes
100 ug
£671.00
6368-MSM4-P1-100UG
About this Product
- SKU:
- 6368-MSM4-P1
- Additional Names:
- CK-beta-8 | Macrophage inflammatory protein 3 | Myeloid progenitor inhibitory factor 1 | Small-inducible cytokine A23
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- CCL23/4034
- Clonality:
- Monoclonal
- Extra Details:
- Small inducible cytokine A23 precursor (CCL23); or CK-b-8; is a chemokine that binds to the receptor CCR1. It is involved in the immune response and inhibits production of polymorphonuclear leukocytes (PMNs) and monocytes in bone marrow. In addition; CCL23 has a splice variant; CK-b-8-1; and both variants chemoattract lymphocytes; monoctyes and neutrophils. CCL23 also promotes angiogenesis and endothelial cell migration via its actions on the CCR1 receptor. Proinflammatory proteases cleave an N-terminal domain of CCL23; improving the potency of its CCR1-mediated signaling up to 1000- fold in vitro. N-truncated CCL23 is found in high levels in synovial fluids of rheumatoid arthritis patients; suggesting a role of protease release during an inflammatory response. High levels of CCL23 mRNA expression occur in human fetal bone osteoblasts and chondrocytes; indicating a possible role for CCL23 in the recruitment of osteoclast precursors to the sites of bone reabsorption.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa1-120) of human CCL23 protein (exact sequence is proprietary)
- Isotype:
- IgG2
- Molecular Weight:
- 13kDa
- Research Area:
- AKT Signaling; Cardiovascular; Endothelial Cell Marker; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=131751
