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Antibodies

Squamous Cell Carcinoma Antigen 1 Antibody

Product Sizes
100 ug
£671.00
6317-MSM1-P1-100UG
About this Product
SKU:
6317-MSM1-P1
Additional Names:
Protein T4-A | Squamous cell carcinoma antigen 1
Application:
Western Blot
translate.label.attr.clone:
CPTC-SERPINB3-2
Clonality:
Monoclonal
Extra Details:
Metastasis of a primary tumor to a distant site is determined through signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine proteases; such as neutrophil elastase. Serpins are family of serine protease inhibitors; contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Serine proteases bind to this substrate mimic in a 1:1 stoichiometric fashion and become catalytically inactive. Aberrant expression of serpin family members can contribute to a number of conditions; including emphysema (-1 antitrypsin deficiency); fatal bleeding (elastase to Thrombin specificity) and thrombosis (antithrombin deficiency); and are indicators of cancer stage phenotypes (circulating levels of squamous cell carcinoma antigen; known as SCCA1; increase in advancing stages of some cervical; lung; esophageal and head and neck cancers). SCCA1 expression has been demonstrated to promote oncogenic transformation and epithelial-mesenchymal transition (EMT) in mammary epithelial cells; and its silencing in breast cancer cells has been shown to halt their proliferation.
Host:
Mouse
Immunogen:
Recombinant human full-length SERPINB3 protein
Isotype:
IgG1
Molecular Weight:
39kDa
Research Area:
Immunology
Shipping Conditions:
Blue Ice
Storage Conditions:
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplier:
NeoBiotechnologies
Type:
Antibodies: Monoclonal Antibody