ROR-gamma / RORC (RAR-related Orphan Receptor C) Antibody
Product Sizes
100 ug
£671.00
6097-MSM1-P1ABX-100UG
About this Product
- SKU:
- 6097-MSM1-P1ABX
- Additional Names:
- Nuclear receptor RZR-gamma | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C | Retinoid-related orphan receptor-gamma
- Application:
- Flow Cytometry, Immunohistochemistry
- translate.label.attr.clone:
- RORC/2941
- Clonality:
- Monoclonal
- Extra Details:
- This MAb recognizes a protein of 63kDa; identified as ROR-C. Its epitope maps in between aa1-50. The nuclear orphan receptors ROR伪 and ROR纬 are members of the nuclear hormone receptor superfamily. Members of this family act by directly associating with DNA sequences known as hormone response elements (HREs) and typically bind DNA as either homo- or heterodimers. RORalpha and RORgamma are unique in that they bind DNA as monomers. RORalpha has multiple isoforms that share common DNA and putative ligand-binding domains; but differ in their amino terminal domains; which are generated by alternative RNA processing. RORgamma comprises a 560 amino acid protein that shares 50% amino acid identity with RORalpha and is most highly expressed in skeletal muscle. Although these proteins are considered orphan receptors; due to a lack of defined ligands; experimental evidence has shown that melatonin may be the natural ligand for these nuclear receptors.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human RORC protein
- Isotype:
- IgG2a
- Molecular Weight:
- 63kDa
- Research Area:
- Cytokine Signaling; Immunology; Nuclear Marker; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=120818
