Bcl-6 (Follicular Lymphoma Marker) Antibody
Product Sizes
20 ug
£364.00
604-MSM12-P0-20UG
About this Product
- SKU:
- 604-MSM12-P0
- Additional Names:
- B-cell lymphoma 5 protein | Protein LAZ-3 | Zinc finger and BTB domain-containing protein 27 | Zinc finger protein 51
- Application:
- ELISA, Immunohistochemistry
- translate.label.attr.clone:
- BCL6/1982
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of 95kDa; which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL); where CD10; bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ('LH') cells of NLPHL are bcl-6 positive. In contrast; anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
- Host:
- Mouse
- Immunogen:
- Recombinant human bcl-6 protein fragment (around aa256-389) (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 95kDa
- Research Area:
- Cancer; Cardiovascular; Cytokine Signaling; Immunology; Nuclear Marker; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=120783
