RENT1 / hUPF1 Antibody
Product Sizes
100 ug
£671.00
5976-MSM1-P1ABX-100UG
About this Product
- SKU:
- 5976-MSM1-P1ABX
- Additional Names:
- ATP-dependent helicase RENT1 | Nonsense mRNA reducing factor 1 (NORF1) | Up-frameshift suppressor 1 homolog (hUpf1) | Regulator of nonsense transcripts 1 | UPF1 RNA helicase and ATPase
- Application:
- ELISA
- translate.label.attr.clone:
- NY1.1.1B6
- Clonality:
- Monoclonal
- Extra Details:
- In eukaryotes; it is essential to have the ability to detect and degrade transcripts that lack full coding potential. Nonsense-mediated RNA decay (NMD) protects the organism by avoiding the translation of truncated peptides with dominant negative or deleterious gain-of-function potential. Rent1; a mammalian ortholog of Upflp; is essential for embryonic viability. Rent1 (also designated regulator of nonsense transcripts and HUpf1) contains an N-terminal zinc finger-like domain; NTPase domains and a region comprised of domains that define Rent1 as a superfamily group I helicase. Rent1 protein has nucleic-acid-dependent ATPase activity and 5' to 3' helicase activity. In addition; Rent1 is an RNA-binding protein whose activity is modulated by ATP and directly interacts with Rent2; which is a mammalian homolog of Upf2p. Two mammalian orthologs to Upf3p; Rent3a and Rent3b; are encoded by two separate genes. Rent3b (also known as Rent3X) is encoded by a X-linked gene and localizes primarily to the nucleus; while Rent1 and Rent2 localize primarily in the cytoplasm. Specific Rent3 protein interactions with Y14 and spliced mRNA suggest Rent3a and Rent3b serve as a link between splicing and NMD in the cytoplasm.
- Host:
- Mouse
- Immunogen:
- Recombinant human UPF1 protein
- Isotype:
- IgG2b
- Molecular Weight:
- 124kDa
- Research Area:
- Cancer; Epigenetics
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=149767
