Cyclin D1 (G1-Cyclin & Mantle Cell Marker) Antibody
Product Sizes
100 ug
£671.00
595-MSM1-P1-100UG
About this Product
- SKU:
- 595-MSM1-P1
- Additional Names:
- B-cell lymphoma 1 protein | BCL-1 oncogene | PRAD1 oncogene
- Application:
- Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- DCS-6
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of 36kDa; identified as cyclin D1. Cyclin D1; one of the key cell cycle regulators; is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). About 40% of breast carcinomas are positive for Cyclin D1. Occasionally; hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
- Host:
- Mouse
- Immunogen:
- Human full length recombinant cyclin D1 protein
- Isotype:
- IgG2a
- Molecular Weight:
- 36kDa
- Research Area:
- AKT Signaling; Bladder Cancer; Breast Cancer; Cancer; Cardiovascular; Colon Cancer; Cytokine Signaling; Immunology; Infectious Disease; Lung Cancer; Nuclear Marker; Signal Transduction; Transcription
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=120542
