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Antibodies

Recombinant Parvalbumin / PVALB Antibody

Product Sizes
100 ug
£671.00
5816-MSM6-P1ABX-100UG
About this Product
SKU:
5816-MSM6-P1ABX
Application:
Western Blot
translate.label.attr.clone:
rPVALB/9839
Clonality:
Monoclonal
Extra Details:
The family of EF-hand type Ca2+-binding proteins includes calbindin (previously designated vitamin D-dependent Ca2+-binding protein); S-100α and β; calgranulins A (also designated MRP8); B (also designated MRP14) and C (S-100 like proteins) and the parvalbumin family members; including parvalbumin α and parvalbumin β; also designated oncomodulin (OCM). Structurally and evolutionarily conserved; parvalbumin α and OCM proteins are distinct in expression and function. Parvalbumin α; also designated parvalbumin (PV); is most abundantly expressed in fast-contracting muscles with lower expression levels in brain and some endocrine tissues; including kidney and parathyroid. Research indicates that parvalbumin α plays a significant role in muscle relaxation. OCM was originally thought to have expression restricted to neoplastic tissues; early embryonic cells and certain tumor cell lines. Recent research shows that OCM is also expressed and secreted by macrophages where; in the retina it binds to retinal ganglion cells (RGCs) and functions to promote axon regeneration. OCM has also been detected in the auditory sensory cells of the organ of Corti in mammals. In humans; two different loci on chromosome 7 have been identified as OCM and OCM-like (LOC4951). These genes encode proteins 109 amino acids in length which share 99% sequence identity.
Host:
Mouse
Immunogen:
Recombinant fragment (around aa1-110) of human PVALB protein (exact sequence is proprietary)
Isotype:
IgG1
Molecular Weight:
12kDa
Research Area:
Neuroscience
Shipping Conditions:
Blue Ice
Storage Conditions:
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplier:
NeoBiotechnologies
Type:
Antibodies: Monoclonal Antibody