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Antibodies

CD45 / LCA (Leucocyte Marker) Antibody

Product Sizes
0.5 ml at 100ug/ml
£671.00
5788-MSM5X-FITC-100T-0.5MLAT100UG
About this Product
SKU:
5788-MSM5X-FITC-100T
Additional Names:
Leukocyte common antigen | T200
Application:
Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
translate.label.attr.clone:
SPM569 + SPM570
Clonality:
Monoclonal
Extra Details:
Recognizes the CD45 leukocyte common antigen (LCA) family which is comprised of at least four isoforms of membrane glycoproteins (220; 205; 190; 180kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines; normal and malignant non-hematopoietic tissues. The intracellular portions of these molecules have protein phosphatase activity and are involved in regulation of transmembrane signals. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms. A positive result with this MAb is highly indicative of lymphoid or myeloid origin. Certain types of lymphoid neoplasms may lack CD45 (Hodgkin lymphoma; some T-cell lymphomas; and some leukemias) so its absence does not rule out a hematolymphoid tumor. This antibody is expressed almost exclusively by cells of hematopoietic lineage and is present in most benign and malignant lymphocytes as well as plasma cell precursors.
Host:
Mouse
Immunogen:
Human B- and T-lymphoma cells
Isotype:
IgG1
Molecular Weight:
180-220kDa
Research Area:
Autophagy; B Cell Markers; Cancer; Dendritic Cell Marker; Developmental Biology; Hematopoietic Stem Cells; Immuno Oncology; Immunology; Mesenchymal Stem Cell Differentiation
Shipping Conditions:
Blue Ice
Storage Conditions:
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplier:
NeoBiotechnologies
Type:
Antibodies: Monoclonal Antibody