SLAMF7 / CS1 / CD319 (NK Cell Marker) Antibody
Product Sizes
100 ug
£671.00
57823-MSM3-P1-100UG
About this Product
- SKU:
- 57823-MSM3-P1
- Additional Names:
- CD2 subset 1 | CD2-like receptor-activating cytotoxic cells | Membrane protein FOAP-12 | Novel Ly9 | Protein 19A
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- SLAMF7/13123
- Clonality:
- Monoclonal
- Extra Details:
- CS1; also known as novel Ly9; SLAMF7; 19A24 or CRACC; is a homophilic cell surface receptor. It is a member of the SLAM (signaling lymphocytic activation molecule) family of receptors expressed on natural killer (NK) cells; T cells and stimulated B cells. CS1 contains immunoreceptor tyrosine-based switch motifs in its cytoplasmic domain but; unlike other SLAM receptors; it does not recruit SAP (SLAM-associated protein). In humans; CS1 activates NK cells through an EAT-2-mediated pathway that is SAP-independent. CS1 recruits and associates with EAT-2; a protein closely related to SAP. EAT-2 induces phosphorylation of CS1 which then; upon ligand binding; activates downstream cytotoxicity effectors PLC and PI 3K. In mice; the EAT-2 association with CS1 has an inhibitory effect on the activation of NK cells.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa200-335) of human SLAMF7 protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 37kDa
- Research Area:
- Dendritic Cell Marker; Immune checkpoint; Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=141883
