KIAA1967 / DBC1 / CCAR2 Antibody
Product Sizes
100 ug
£671.00
57805-MSM3-P1ABX-100UG
About this Product
- SKU:
- 57805-MSM3-P1ABX
- Additional Names:
- Cell division cycle and apoptosis regulator protein 2 | DBIRD complex subunit KIAA1967 | Deleted in breast cancer gene 1 protein | NET35 | p30 DBC
- Application:
- Flow Cytometry, Immunohistochemistry
- translate.label.attr.clone:
- PCRP-KIAA1967-1D10
- Clonality:
- Monoclonal
- Extra Details:
- DBC-1 (deleted in breast cancer gene 1 protein); also known as p30 DBC protein; is one of the genes located within the region of chromosome 8p21.3 that is homozygously deleted in some breast cancers. DBC-1 contains a nuclear localization signal; an N-terminal leucine zipper; an EF hand and a C-terminal coiled-coil region. DBC-1 is closely related to DIS but lacks the SAP domain. During death signaling mediated by TNFα; endogenous DBC-1 undergoes caspase-dependent processing to generate DBC-1 p120 and p66; both of which include the C-terminus of the protein. Both DBC-1 p120 and p66 relocate to the cytoplasm. Overexpression of the DBC-1 p120 form results in mitochondrial clustering and matrix condensation and increases the sensitivity of cells to TNFα-mediated apoptosis. In addition; DBC-1 directly interacts with unliganded ERα; stabilizing its expression and therefore collaborating to suppress apoptosis and promote hormone-independent cell growth.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human CCAR2 / KIAA1967 protein
- Isotype:
- IgG2a
- Molecular Weight:
- 102.9kDa
- Research Area:
- Apoptosis; Autophagy; Cardiovascular; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=129611
