ZFYVE28 (Zinc Finger FYVE-type containing 28) Antibody
Product Sizes
20 ug
£364.00
57732-MSM1-P0-20UG
About this Product
- SKU:
- 57732-MSM1-P0
- Additional Names:
- Zinc finger FYVE domain-containing protein 28
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- LST2/2426
- Clonality:
- Monoclonal
- Extra Details:
- ZFYVE28 belongs to the lst-2 family. It contains 1 FYVE-type zinc finger. The FYVE-type zinc finger mediates the interaction with phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes when not mono-ubiquitinated at Lys-87. Mono-ubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes. ZFYVE28 is a negative regulator of epidermal growth factor receptor (EGFR) signaling. It acts by promoting EGFR degradation in endosomes when not mono-ubiquitinated. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human LST2/ ZFYVE28 protein
- Isotype:
- IgG2a
- Molecular Weight:
- 96kDa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=120240
