Cycloxygenase-2 (COX-2) Antibody
Product Sizes
100 ug
£671.00
5743-MSM2-P1ABX-100UG
About this Product
- SKU:
- 5743-MSM2-P1ABX
- Additional Names:
- Cyclooxygenase-2 | PHS II | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- COX2/2377
- Clonality:
- Monoclonal
- Extra Details:
- Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA). Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS). Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs; NSAIDs. COX2 expression is significantly increased in 85-90% of human colorectal adenocarcinomas whereas levels of COX-1 are not changed.
- Host:
- Mouse
- Immunogen:
- Recombinant human COX2 protein fragment (around aa 442-572) (exact sequence is proprietary)
- Isotype:
- IgG2a
- Molecular Weight:
- 70-72kDa
- Research Area:
- Angiogenesis; Cardiovascular; Colon Cancer; Cytokine Signaling; Immunology; Lung Cancer; Neuroscience
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=120213
