MAPK1 / ERK2 (Transcription Factor) Antibody
Product Sizes
100 ug
£671.00
5594-MSM3-P1-100UG
About this Product
- SKU:
- 5594-MSM3-P1
- Additional Names:
- ERT1 | Extracellular signal-regulated kinase 2 | MAP kinase isoform p42 | Mitogen-activated protein kinase 2
- Application:
- ELISA, Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- PCRP-MAPK1-1D1
- Clonality:
- Monoclonal
- Extra Details:
- Mitogen-activated protein kinase (MAPK) signaling pathways involve two closely-related MAP kinases; known as extracellular-signal-related kinase 1 (ERK 1; p44) and 2 (ERK 2; p42). Growth factors; steroid hormones; G protein coupled receptor ligands and neurotransmitters can initiate MAPK signaling pathways. Activation of ERK 1 and ERK 2 requires phosphorylation by upstream kinases such as MAP kinase (MEK); MEK kinase and Raf-1. ERK 1 and ERK 2 phosphorylation can occur at specific tyrosine and threonine sites mapping within consensus motifs that include the threonine-glutamate-tyrosine motif. ERK activation leads to dimerization with other ERKs and subsequent localization to the nucleus. Active ERK dimers phosphorylate serine and threonine residues on nuclear proteins and influence a host of responses that include proliferation; differentiation; transcription regulation and development.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human MAPK1 protein
- Isotype:
- IgG2b
- Molecular Weight:
- 41.3kDa
- Research Area:
- Bladder Cancer; Breast Cancer; Cardiovascular; Colon Cancer; Cytokine Signaling; Developmental Biology; Immunology; Infectious Disease; MAPK Signaling; Neuroinflammation; Ovarian Cancer; Signal Transd
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=120003
