MBNL3 Antibody
Product Sizes
100 ug
£671.00
55796-MSM1-P1-100UG
About this Product
- SKU:
- 55796-MSM1-P1
- Additional Names:
- Cys3His CCG1-required protein | Muscleblind-like X-linked protein | Protein HCHCR
- Application:
- Flow Cytometry
- translate.label.attr.clone:
- PCRP-MBNL3-1D11
- Clonality:
- Monoclonal
- Extra Details:
- Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Several protein complexes are involved in proper mRNA splicing and transport. The muscleblind proteins; MBNL1; MBNL2 and MBNL3; promote inclusion or exclusion of specific exons on different pre-mRNAs by antagonizing the activity of CUG-BP and ETR-3-like factors bound to distinct intronic sites. MBNL1 and 2; which associate with expanded CUG repeats in vitro; localize to the nuclear foci in both DM1 and DM2 (myotonic dystrophy types 1 and 2); suggesting that the nuclear accumulation of mutant RNA is pathogenic in DM1; therefore implicating MBNL1 and 2 in the pathogenesis of both disorders. MBNL3; a 354 amino acid protein; inhibits expression of muscle differentiation; opposite to the function of MBNL1; which functions as a promoter of muscle differentiation. MBNL3 shows strong expression in placenta.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human MBNL3 protein
- Isotype:
- IgG2b
- Molecular Weight:
- 39kDa
- Research Area:
- Cardiovascular; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=120000
