MAML3 (Mastermind Like Transcriptional Coactivator 3) Antibody
Product Sizes
100 ug
£671.00
55534-MSM1-P1ABX-100UG
About this Product
- SKU:
- 55534-MSM1-P1ABX
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- MAML3/1303
- Clonality:
- Monoclonal
- Extra Details:
- MAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region; MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1; Notch 2; Notch 3 and Notch 4.This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-J a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding; the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation; upregulation of MAML3 is thought to be involved in oncogenesis.
- Host:
- Mouse
- Immunogen:
- Recombinant human MAML3 protein fragment
- Isotype:
- IgG1
- Molecular Weight:
- 150-170kDa
- Research Area:
- Developmental Biology; Infectious Disease; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=119944
