Perforin-1 (Pore Forming Protein) (Apoptosis Marker) Antibody
Product Sizes
100 ug
£671.00
5551-MSM1-P1ABX-100UG
About this Product
- SKU:
- 5551-MSM1-P1ABX
- Additional Names:
- Cytolysin | Lymphocyte pore-forming protein
- Application:
- ELISA
- translate.label.attr.clone:
- PRF1/2467
- Clonality:
- Monoclonal
- Extra Details:
- Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9). Like C9; this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules; and is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2); a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8+ T-cells; natural killer cells and some CD4+ T-cells.
- Host:
- Mouse
- Immunogen:
- Recombinant human Perforin-1 protein fragment (around aa 413-552) (exact sequence is proprietary)
- Isotype:
- IgG2b
- Molecular Weight:
- 75kDa
- Research Area:
- Apoptosis; Autophagy
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=119917
