Calcineurin A / PPP3CA Antibody
Product Sizes
100 ug
£671.00
5530-MSM2-P1ABX-100UG
About this Product
- SKU:
- 5530-MSM2-P1ABX
- Additional Names:
- CAM-PRP catalytic subunit | Calcineurin A alpha | Calmodulin-dependent calcineurin A subunit alpha isoform | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- CALNA/2353
- Clonality:
- Monoclonal
- Extra Details:
- Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59kDa catalytic A subunit and a 19kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues; but its levels are highest in the brain; where it may play a role in learning and memory. It has many substrates; including NFAT; a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human Calcineurin A protein
- Isotype:
- IgG1
- Molecular Weight:
- 62kDa
- Research Area:
- Cardiovascular; Immunology; MAPK Signaling; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=119913
