PRMT6 Antibody
Product Sizes
100 ug
£671.00
55170-MSM2-P1ABX-100UG
About this Product
- SKU:
- 55170-MSM2-P1ABX
- Additional Names:
- Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 | Histone-arginine N-methyltransferase PRMT6
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- PCRP-PRMT6-2C9
- Clonality:
- Monoclonal
- Extra Details:
- A class of proteins termed type 1 protein arginine N-methyltransferase (PRMT) enzymes contribute to posttranslational modification of RNA-binding proteins; but differ in substrate specificities; oligomerization properties and subcellular localization. PRMTs contain an S-adenosylmethione motif which functions to add one or two methyl groups to guanidino nitrogens of arginine (R) side chains. PRMT6; also known as HRMT1L6; is a nuclear protein belonging to the PRMT family and is predominantly expressed in testis and kidney. It is known to methylate Histones H3; H4 and H2A. PRMT6 is the major dimethyltransferase for Histone H3 and specifically methylates Histone H3 at R2. Methylation at Histone H3 R2 acts to inhibit Histone H3 K4 trimethylation and ultimately leads to the transcriptional repression of genes that are activated by Histone H3 K4 trimethylation. In addition; PRMT6 methylates HIV TAT; possibly functioning as a form of cellular innate immunity to restrict levels of HIV replication.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human PRMT6 protein
- Isotype:
- IgG2b
- Molecular Weight:
- 42kDa
- Research Area:
- Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=119887
