Recombinant BCOR Antibody
Product Sizes
20 ug
£364.00
54880-RBM5-P0-20UG
About this Product
- SKU:
- 54880-RBM5-P0
- Additional Names:
- BCOR; KIAA1575
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- BCOR/13087R
- Clonality:
- Monoclonal
- Extra Details:
- Bcl-6; a transcriptional repressor; can promote or inhibit apoptosis depending on the cell type and also plays an important role in normal immune responses. Bcl-6 negatively regulates NFkB expression; thereby inhibiting NFkB-mediated cellular functions and is frequently found to be deregulated in non-Hodgkin’s lymphoma. BCoR (Bcl-6 corepressor) is a 1;755 amino acid protein that associates with histone deacetylases (HDACs) to transcriptionally repress Bcl-6. With ubiquitous expression; BCoR is localized to the nucleus where it interacts with other proteins through its three ANK repeat domains. Mutations in the gene encoding BCoR result in microphthalmia with associated anomalies 2; also known as anophthalmia; which is characterized by variable features; such as renal aplasia; mental retardation; hyospadias; microencephaly and cryptorchidism. There are four isoforms of BCoR which are produced as a result of alternative splicing events.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa 100-400) of human BCOR protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 192kDa
- Research Area:
- Epigenetics
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=143975
