Recombinant ATRX / RAD54 (Alpha Thalassemia Mental Retardation) Antibody
Product Sizes
100 ug
£671.00
546-RBM8-P1-100UG
About this Product
- SKU:
- 546-RBM8-P1
- Additional Names:
- ATP-dependent helicase ATRX | X-linked helicase II | X-linked nuclear protein | Znf-HX
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- ATRX/7188R
- Clonality:
- Monoclonal
- Extra Details:
- ATRX is a member of the Snf2 family of helicase/ATPases; which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner; and facilitate the initiation of transcription and replication. Structurally; ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase; ATRX predominately associates with the nuclear matrix; while during mitosis; ATRX localizes with condensed chromatin. At the onset of M phase; phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes; where it then specifically complexes with heterochromatin protein 1 伪 to mediate chromosomal segregation. Mutations in the ATRX gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with 伪 thalassemia or ATRX syndrome
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa2200-2450) of human ATRX protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 280kDa
- Research Area:
- Cardiovascular; Infectious Disease; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=119795
