POU1F1 / PIT-1 Antibody
Product Sizes
100 ug
£671.00
5449-MSM2-P1-100UG
About this Product
- SKU:
- 5449-MSM2-P1
- Additional Names:
- Growth hormone factor 1
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- PIT1/7262
- Clonality:
- Monoclonal
- Extra Details:
- Transcriptional regulators play a critical role in development by mediating tissue- and cell-specific transcription. POU domain factors are transcriptional regulators characterized by a bipartite DNA binding domain; which consists of two highly conserved regions; tethered by a variable linker of 14-26 amino acids. Pit-1; also known as growth hormone factor-1 (GHF-1); a member of the POU homeodomain family; is essential for the normal development of the anterior pituitary gland; where it is required for the formation of somatotropes; lactotropes and thyrotropes. In somatotropes and lactotropes; Pit-1 activates the production of growth hormone and Prolactin; respectively. In addition; Pit-1 acts as a repressor of gene expression; which allows for the differentiation of specific cell types. Pit-1 is expressed as two alternatively spliced products; designated Pit-1a and Pit-1b; which differ in their trans-activation ability. Mutations in the Pit-1 gene are believed to result in combined pituitary hormone deficiency (CPHD) for growth hormone; Prolactin and thyroid stimulating hormone. The gene which encodes Pit-1 maps to human chromosome 3p11.2.
- Host:
- Mouse
- Immunogen:
- Recombinant human full-length POU1F1 protein
- Isotype:
- IgG2b
- Molecular Weight:
- 31-35kDa
- Research Area:
- Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=119734
