Recombinant ACTH (Adrenocorticotrophic Hormone) (N-Terminal) (Pituitary Marker) Antibody
Product Sizes
20 ug
£364.00
5443-RBM17-P0-20UG
About this Product
- SKU:
- 5443-RBM17-P0
- Additional Names:
- Corticotropin-lipotropin | Gamma-MSH | Adrenocorticotropic hormone | Melanotropin alpha | Beta-LPH | Gamma-LPH | Melanotropin beta
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- CLIP/7197R
- Clonality:
- Monoclonal
- Extra Details:
- ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive; tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP; ACTH; alpha-MSH (Melanocyte Stimulating Hormone); beta-MSH; gamma-MSH; CLIP (corticotropin-like intermediary peptide); Lipotropin-beta; Lipotropin-gamma; beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells; B-cells; and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). ÔøΩIt also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH. ÔøΩ ÔøΩ
- Host:
- Rabbit
- Immunogen:
- N-terminal fragment of human ACTH conjugated to KLH
- Isotype:
- IgG
- Molecular Weight:
- ACTH is ~5kDa|and the POMC precursor is ~30kDa. The molecular weight of POMC depends upon isoform va
- Research Area:
- Cytokine Signaling; Immunology; Infectious Disease; Neuroscience; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=131177
