RNA Polymerase II CTD Repeat YSPTSPS (Phospho S5) Antibody
Product Sizes
20 ug
£364.00
5430-MSM2-P0-20UG
About this Product
- SKU:
- 5430-MSM2-P0
- Additional Names:
- DNA-directed RNA polymerase II subunit A | DNA-directed RNA polymerase III largest subunit | RNA-directed RNA polymerase II subunit RPB1
- Application:
- Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- CTD 8A7
- Clonality:
- Monoclonal
- Extra Details:
- RNA polymerase II (Pol II) is an enzyme that is composed of 12 subunits and is responsible for the transcription of protein-coding genes. Transcription initiation requires Pol II-mediated recruitment of transcription machinery to a target promoter; thereby allowing transcription to begin. The largest subunit of Pol II (referred to as RPB1 or RPB205) is a 1;840 amino acid protein that contains one C2H2-type zinc finger and a C-terminal domain comprised of several heptapeptide repeats. Although Pol II function requires the cooperation of all twelve subunits; the largest subunit conveys Pol II catalytic activity and; together with the second largest subunit; forms the active center of the Pol II enzyme. Additionally; the large subunit participates in forming the DNA-binding domain of Pol II; a groove that is necessary for transcription of the DNA template. Without proper function of the large subunit; mRNA synthesis and subsequent transcription elongation cannot occur.
- Host:
- Mouse
- Immunogen:
- Ten repeats of synthetic peptide YSPTSPS using chemically synthesized phospho-Ser5
- Isotype:
- IgM
- Molecular Weight:
- 192-253kDa
- Research Area:
- Cardiovascular; Developmental Biology; Infectious Disease; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=119617
