TREM2 (Triggering Receptor Expressed On Myeloid Cells 2) Antibody
Product Sizes
100 ug
£671.00
54209-MSM1-P1ABX-100UG
About this Product
- SKU:
- 54209-MSM1-P1ABX
- Additional Names:
- Triggering receptor expressed on monocytes 2
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- TREM2/7210
- Clonality:
- Monoclonal
- Extra Details:
- Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); known as Nasu-Hakola disease ; is a recessively inherited disease where individuals display early-onset progressive dementia and bone cysts; which leads to death. Mutations in TYROBP (DAP12); which codes for a membrane receptor component in natural-killer and myeloid cells and mutations in triggering receptor expressed on myeloid cells-2 (TREM-2); correlate well to the pathology of PLOSL. TREM-2 is a cell surface receptor on human monocyte-derived dendritic cells that forms a receptor signaling complex with DAP12 and triggers activation of the immune response in macrophages and dendritic cells (DC). The TREM-2/DAP12 complex is a molecular promoter of upregulation of CC chemokine receptor 7; partial DC maturation; and DC survival through activation of protein tyrosine kinases and extracellular signal regulated kinase. The human chronic inflammatory TREM-2 gene maps to chromosome 6p21.1 and encodes a 230 amino acid protein.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa1-200) of human TREM2 protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 40kDa (glycosylated); 26kDa (deglycosylated)
- Research Area:
- Cardiovascular; Dendritic Cell Marker; Developmental Biology; Immunology; Neuroscience
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=119615
