Cytochrome C (Mitochondrial Marker) Antibody
Product Sizes
100 ug
£671.00
54205-MSM1-P1-100UG
About this Product
- SKU:
- 54205-MSM1-P1
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- 6H2.B4
- Clonality:
- Monoclonal
- Extra Details:
- Cytochrome c is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells; this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis; cytochrome c is trans-located from the mitochondrial membrane to the cytosol; where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c; thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade; whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner; leading to caspase-9 cleavage of caspase-3.
- Host:
- Mouse
- Immunogen:
- Rat full-length cytochrome c protein
- Isotype:
- IgG1
- Molecular Weight:
- 15kDa
- Research Area:
- Apoptosis; Autophagy; Cardiovascular; Complement System; Lung Cancer; Mitochondria Marker; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=119584
