PMS1 Antibody
Product Sizes
100 ug
£671.00
5378-MSM1-P1-100UG
About this Product
- SKU:
- 5378-MSM1-P1
- Additional Names:
- DNA mismatch repair protein PMS1
- Application:
- ELISA, Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- PCRP-PMS1-2E11
- Clonality:
- Monoclonal
- Extra Details:
- The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially; inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic; gastric; breast; ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene; designated PMS1 and PMS2; have been identified and shown to be mutated in the germline of HNPCC patients.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human PMS1 protein
- Isotype:
- IgG1
- Molecular Weight:
- 105.8kDa
- Research Area:
- Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=119525
