MBD3 Antibody
Product Sizes
100 ug
£671.00
53615-MSM1-P1-100UG
About this Product
- SKU:
- 53615-MSM1-P1
- Additional Names:
- Methyl-CpG-binding protein MBD3
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- PCRP-MBD3-1C4
- Clonality:
- Monoclonal
- Extra Details:
- Methylation of DNA contributes to the regulation of gene transcription in both mammalian and invertebrate systems. DNA methylation predominates on cytosine residues that are present in dinucleotide motifs consisting of a 5' cytosine followed by guanosine (CpG); and it requires the enzymatic activity of DNA methyltransferase; which results in transcriptional repression of the methylated gene. Several proteins have been identified that associate with the methyl-CpG sites; they include methyl-CpG binding protein 1 (MBD1); MBD2; MBD3; MBD4 and MeCP2. Expression of the MBD proteins is highest in somatic tissues. MBD1 binds in a context specific manner to methyl-CpG rich domains and; in turn; mediates the transcriptional inhibition that is commonly observed with DNA methylation. Similarly; MBD2 inhibits transcription of methylated genes by associating with histone deacetylase (HDAC1) within the MeCP1 repressor complex. In addition; MBD4; which is also designated MED1; associates with the mismatch repair protein MLH1 and preferentially binds to methylated cytosine residues in mismatched base pairs. MeCP2 binds tightly to chromosomes in a methylation-dependent manner and associates with a corepressor complex containing the transcriptional repressor mSin3A and histone deacetylases. MeCP2 binds tightly to chromosomes in a methylation-dependent manner and associates with a corepressor complex containing the transcriptional repressor mSin3A and histone deacetylases.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human MBD3 protein
- Isotype:
- IgG2b
- Molecular Weight:
- 34kDa
- Research Area:
- Infectious Disease; Nuclear Marker; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=119524
