PIK3CD Antibody
Product Sizes
20 ug
£364.00
5293-MSM9-P0-20UG
About this Product
- SKU:
- 5293-MSM9-P0
- Additional Names:
- Phosphatidylinositol 4; 5-bisphosphate 3-kinase 110 kDa catalytic subunit delta
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- PIK3CD/4639
- Clonality:
- Monoclonal
- Extra Details:
- Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter; coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85a and p85b); each possessing one SH3 and two SH2 domains. Various p110 forms have been identified. p110a and p110b interact with p85a; and p110a has also been shown to interact with p85b in vitro. It has been shown to bind p85a and b; but it apparently does not phosphorylate these subunits. p110d has the capacity to autophosphorylate and results in the nearly complete inactivation of the lipid kinase activity. Interestingly; p110g does not interact with the p85 subunits and has been shown to be activated by a and bg heterotrimeric G proteins. Two p110d isoforms have been identified and are widely expressed. Isoform 1 is expressed predominantly in leukocytes while isoform 2 is expressed in normal thymus; lung and spleen tissues.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human PIK3CD protein (around aa 520-720) (exact sequence is proprietary)
- Isotype:
- IgG2b
- Molecular Weight:
- 119/33kDa
- Research Area:
- BBB VCAM-1 Signaling; Breast Cancer; CTLA-4 blockade immunotherapy; Cardiovascular; Cytokine Signaling; Developmental Biology; Immunology; Infectious Disease; Lung Cancer; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=135311
