Recombinant P-glycoprotein / p170 / MDR1 / CD243 Antibody
Product Sizes
20 ug
£364.00
5243-RBM4-P0-20UG
About this Product
- SKU:
- 5243-RBM4-P0
- Additional Names:
- ATP-binding cassette sub-family B member 1 | Multidrug resistance protein 1 | P-glycoprotein 1 | Phospholipid transporter ABCB1
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- MDR1/8962R
- Clonality:
- Monoclonal
- Extra Details:
- Cells selected for resistance to a single cytotoxic drug may become crossresistant to a broad range of drugs with different structures and cellular targets. This phenomenon is called multiple drug resistance (MDR). MDR proteins (Mdrs) are members of a highly conserved superfamily of ATP-binding cassette transport proteins. Mdr-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug-transport pump transporting a variety of drugs from the brain back into the blood. The Mdr-1 gene is known as ABCB1 and is located on human chromosome 7q21.12. The mouse homolog of Mdr-1 is known as Mdr-3. Interestingly; a murine protein by the name of Mdr-1 exists and is encoded by the murine Abcb1b gene; but it is not homologous with human Mdr-1.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa500-700) of human ABCB1 protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 170kDa
- Research Area:
- Cardiovascular
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=131118
