Recombinant Progesterone Receptor (Marker of Progestin Dependence) Antibody
Product Sizes
100 ug
£671.00
5241-RBM12-P1-100UG
About this Product
- SKU:
- 5241-RBM12-P1
- Additional Names:
- Nuclear receptor subfamily 3 group C member 3
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- PGR/6854R
- Clonality:
- Monoclonal
- Extra Details:
- Progesterone is one of the central regulators of female reproduction. In breast development; progesterone is involved in the formation of lobular-alveolar structures and also affects differentiation in the breast by modulation of milk protein synthesis. The cellular effects of progesterone are mediated through progesterone receptors (PR). PR; a protein with 946 amino acids; is a ligand-activated transcription factor member of the steroid receptor super family of nuclear receptors. PR is predominantly expressed in female sex steroid responsive tissues such as the mammary gland; uterus and ovary but is also found in other tissues such as endocrine cells of the Langerhans' islets. The estrogen receptor (ER) and PR status has been used for over 20 years as a predictor of breast carcinoma responsiveness to endocrine therapy and as a prognostic indicator for early recurrence.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa 1-200) of human PGR (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- PR-A (81kDa) and PR-B (116kDa).
- Research Area:
- Breast Cancer; Cardiovascular; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=119406
