TDP2 / EAPII Antibody
Product Sizes
20 ug
£364.00
51567-MSM1-P0-20UG
About this Product
- SKU:
- 51567-MSM1-P0
- Additional Names:
- 5'-tyrosyl-DNA phosphodiesterase | ETS1-associated protein 2 | ETS1-associated protein II | TRAF and TNF receptor-associated protein | Tyrosyl-RNA phosphodiesterase | VPg unlinkase
- Application:
- Flow Cytometry, Immunofluorescence, Immunohistochemistry
- translate.label.attr.clone:
- TDP2/1258
- Clonality:
- Monoclonal
- Extra Details:
- This MAb recognizes a protein of 41kDa; which is identified as TDP2. It is a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40; tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs); and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease; which is involved in both DNA repair and the activation of transcription factors. DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond; giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity; creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity; but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human TDP2 protein
- Isotype:
- IgG2b
- Molecular Weight:
- ~41kDa
- Research Area:
- Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=119253
