PDGFR-A (Platelet Derived Growth Factor Receptor; alpha) / CD140a Antibody
Product Sizes
100 ug
£671.00
5156-MSM1-P1-100UG
About this Product
- SKU:
- 5156-MSM1-P1
- Additional Names:
- Alpha platelet-derived growth factor receptor | Alpha-type platelet-derived growth factor receptor | CD140 antigen-like family member A | CD140a antigen | Platelet-derived growth factor alpha receptor | Platelet-derived growth factor receptor 2
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- PDGFRA/7407
- Clonality:
- Monoclonal
- Extra Details:
- Platelet-derived growth factor (PDGF) is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains; A and B; which dimerize to form functionally distinct isoforms; PGDF-AA; PDGF-AB and PDGF-BB. These three isoforms bind with different affinities to two receptor types; PDGFR-a and -β; which are endowed with protein tyrosine kinase domains. PDGFR-a can bind to both A and B subunits of PDGF; while PDGFR-β can only bind the B subunit. Ligand binding promotes either homo- or heterodimerization of the PDGF receptors in a specific manner. PDGF-AA induces the dimerization of two a receptors; PDGF-AB induces dimerization of aa and aβ and PDGF-BB induces the formation of three types of dimers; aa; aβ and ββ. Translocation of the PDGFR-β gene with the Tel gene is linked to chronic myelomonocytic leukemia (CMML); a myelodysplastic syndrome; and demonstrates the oncogenic potential of the PDGF receptors.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa1-200) of human PDGFRA protein (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 170kDa
- Research Area:
- AKT Signaling; Angiogenesis; Cardiovascular; Infectious Disease; Neural Stem Cells; Nuclear Marker; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=131057
