PDGF beta (PDGFB) Antibody
Product Sizes
100 ug
£671.00
5155-MSM2-P1-100UG
About this Product
- SKU:
- 5155-MSM2-P1
- Additional Names:
- PDGF-2 | Platelet-derived growth factor B chain | Platelet-derived growth factor beta polypeptide | Proto-oncogene c-Sis
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- PDGFB/3072
- Clonality:
- Monoclonal
- Extra Details:
- PDGF is a mitogen for mesenchyme- and glia-derived cells. It consists of two disulfide-bonded polypeptide chains; A and B; and occurs as three isoforms; PDGF AA; AB and BB. The three isoforms bind; with different affinities; to two receptor types; 伪 and 尾; which are structurally related and endowed with protein-tyrosine kinase domains. Ligand binding induces activation of the receptor kinases by formation of receptor dimers; the A subunit of PDGF binds only to 伪 receptors with high affinity; whereas the B subunit can bind to both 伪 and 尾 receptors. Evidence suggests that PDGF may function as a neurotrophic factor. Receptors for PDGF-A are expressed in oligodendrocyte progenitor cells whereas receptors for PDGF-B are expressed on neurons. These facts suggest that the different isoforms of PDGF may regulate growth and differentiation of different cell types in the developing central nervous system through paracrine and autocrine routes.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human PDGFB protein (around aa 27-158) (exact sequence is proprietary)
- Isotype:
- IgG2c
- Molecular Weight:
- 14kDa (monomeric B chain); 31-35kDa (dimer)
- Research Area:
- AKT Signaling; Cardiovascular; Endothelial Cell Marker; Infectious Disease; MAPK Signaling; Mesenchymal Stem Cell Differentiation; Neural Stem Cells; Signal Transduction; Stem Cell Differentiation
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=119252
