Recombinant FOXP3 (Forkhead Box Protein P3) / Scurfin Antibody
Product Sizes
100 ug
£671.00
50943-RBM7-P1ABX-100UG
About this Product
- SKU:
- 50943-RBM7-P1ABX
- Additional Names:
- Scurfin
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- FOXP3/8145R
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of 47-55kDa; which is identified as FOXP3. Its precise epitope is not known; but it has been mapped to the N-terminal portion of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development; FOXP1 and FOXP2 are expressed abundantly in the lung; with lower levels of expression in neural; intestinal and cardiovascular tissues; where they act as transcription repressors. FOXP1 is widely expressed in adult tissues; while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX; a fatal; X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically; FOXP3 represses transcription through a DNA binding forkhead domain; thereby regulating T cell activation.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa300-431) of human FOXP3 protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 47-55kDa
- Research Area:
- Nuclear Marker; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=129610
