PBX1 / PRL (Transcription Factor) Antibody
Product Sizes
20 ug
£364.00
5087-MSM2-P0-20UG
About this Product
- SKU:
- 5087-MSM2-P0
- Additional Names:
- Homeobox protein PBX1 | Homeobox protein PRL
- Application:
- ELISA, Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- PCRP-PBX1-3C8
- Clonality:
- Monoclonal
- Extra Details:
- Pbx 1; 2; 3 and 4 are members of the TALE (three amino acid loop extension) family of homeodomain-containing proteins. Human pre-B cell acute leukemias are frequently associated with a t(1;19)(q23;p13.3) chromosomal rearrangement; which creates a chimeric gene encoding a fusion between the E2A and Pbx 1 gene products. Pbx 2 and Pbx 3 share 92% and 94% respective identities with Pbx 1 over a 266 amino acid region flanking their homeobox domains; while all three proteins are quite divergent at their amino- and carboxy-termini. Two forms of Pbx 1 and Pbx 3 each differ primarily in their carboxy-termini and result from alternative mRNA splicing. Unlike other homeotic selector genes which are expressed transiently during development and differentiation; Pbx gene transcripts are ubiquitously expressed in both fetal and adult tissues and cell lines. Additionally; Pbx 2 and Pbx 3 transcripts are detected in lymphoid cells; which do not express Pbx 1. Pbx 4 expression is confined to the testis; especially to spermatocytes in the pachytene stage of the first meiotic prophase.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human PBX1 protein
- Isotype:
- IgG2b
- Molecular Weight:
- 86.1kDa
- Research Area:
- Cardiovascular; Developmental Biology; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=119133
