NEUROG3 / Neurogenin 3 / NGN3 (Transcription Factor) Antibody
Product Sizes
100 ug
£671.00
50674-MSM2-P1-100UG
About this Product
- SKU:
- 50674-MSM2-P1
- Additional Names:
- Class A basic helix-loop-helix protein 7 | Protein atonal homolog 5
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- NGN3/1809
- Clonality:
- Monoclonal
- Extra Details:
- This antigen is a transcription factor that interacts with NKX2-2 to regulation transcription of NEUROD1. The neurogenin family of proteins belongs to the basic helix-loop-helix (bHLH) superfamily and consists of Neurogenin 1; Neurogenin 2 and Neurogenin 3 (also designated ngn3). bHLH members are transcriptional regulators that determine cell fate. Neurogenin 3 is expressed in discrete regions of developing neurons and in the embryonic pancreatic islets of Langerhans. HNF-6 (hepatocyte nuclear factor 6) acts as a positive regulator of Neurogenin 3 by binding to and stimulating the neurogenin gene promoter. Neurogenin 3 is involved in the initial differentiation of the four islets cell types; while a network of transcription factors; including Hlxb9; Isl1; NeuroD; Nkx-2.2; Nkx-6.4; Pax-4; Pax-6; PDX-1 and Mash1; are required for final differentiation. Neurogenin 3 acts upstream of NeuroD in a bHLH cascade. Neurogenin 3 activates the expression of NeuroD at the onset of islet cell differentiation through box sequences E1 and E3 in the NeuroD promoter.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa1-200) of human NEUROG3 protein (exact sequence is proprietary)
- Isotype:
- IgG2b
- Molecular Weight:
- 23.54kDa
- Research Area:
- Developmental Biology; Nuclear Marker; Stem Cell Differentiation
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=131601
