OTX2 / Orthodenticle homeobox 2 (Transcription Factor) Antibody
Product Sizes
100 ug
£671.00
5015-MSM1-P1ABX-100UG
About this Product
- SKU:
- 5015-MSM1-P1ABX
- Additional Names:
- Orthodenticle homolog 2
- Application:
- ELISA, Flow Cytometry
- translate.label.attr.clone:
- PCRP-OTX2-1E10
- Clonality:
- Monoclonal
- Extra Details:
- Transcription factors OTX1 and OTX2; two murine homologs of the Drosophila orthodenticle (OTD); show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction; specification and regionalization of the brain. OTX1 is involved in corticogenesis; sensory organ development and pituitary functions; while OTX2 is necessary earlier in development; for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm; which is destined to become the fore-midbrain; and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q22.3; respectively.
- Host:
- Mouse
- Immunogen:
- Recombinant human full-lengthOTX2protein
- Isotype:
- IgG1
- Molecular Weight:
- 71.5kDa
- Research Area:
- Nuclear Marker; Stem Cell Differentiation
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=119017
