ORC1 Antibody
Product Sizes
100 ug
£671.00
4998-MSM1-P1-100UG
About this Product
- SKU:
- 4998-MSM1-P1
- Additional Names:
- Replication control protein 1
- Application:
- ELISA
- translate.label.attr.clone:
- 7F6/1
- Clonality:
- Monoclonal
- Extra Details:
- The initiation of DNA replication is a multi-step process that depends on the formation of pre-replication complexes; which trigger initiation. Among the proteins required for establishing these complexes are the origin recognition complex (ORC) proteins. ORC proteins bind specifically to origins of replication where they serve as scaffold for the assembly of additional initiation factors. Human ORC subunits 1-6 are expressed in the nucleus of proliferating cells and tissues; such as the testis. ORC1 and ORC2 are both expressed at equivalent concentrations throughout the cell cycle; however; only ORC2 remains stably bound to chromatin. ORC4 and ORC6 are also expressed constantly throughout the cell cycle. ORC2; ORC3; ORC4 and ORC5 form a core complex upon which ORC6 and ORC1 assemble. The formation of this core complex suggests that ORC proteins play a crucial role in the G1-S transition in mammalian cells.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human ORC1 protein
- Isotype:
- IgG1
- Molecular Weight:
- 120kDa
- Research Area:
- Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=119016
