Nuclear Mitotic Apparatus Protein (NuMA) Antibody
Product Sizes
100 ug
£671.00
4926-MSM1X-P1BX-100UG
About this Product
- SKU:
- 4926-MSM1X-P1BX
- Additional Names:
- Nuclear matrix protein-22 | Nuclear mitotic apparatus protein | SP-H antigen
- Application:
- Flow Cytometry, Immunofluorescence, Immunohistochemistry
- translate.label.attr.clone:
- SPM300
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a phosphorylated protein of 228kDa; identified as nuclear mitotic apparatus protein (NuMA). Its epitope is resistant to phosphatases. NuMA is intra-nuclear protein and present in nucleus during interphase. At the onset of mitosis; it redistributes from the nucleus to two centrosomal structures that later will become part of the mitotic spindle pole. After anaphase; the protein redistributes from the spindle polar region into reforming nucleus. NuMA is an essential protein during mitosis for the terminal phases of chromosome separation and/or nuclear reassembly. Recently a study shows that NuMA is cleaved to a 180 to 200kDa during apoptosis. Chromosomal translocation of this gene with the RARA (retinoic acid receptor; alpha) gene on chromosome 17 has been detected in patients with acute promyelocytic leukemia.
- Host:
- Mouse
- Immunogen:
- Colon carcinoma 174T cells
- Isotype:
- IgM
- Molecular Weight:
- 228kDa
- Research Area:
- Cancer; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=118983
