NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3) Antibody
Product Sizes
100 ug
£671.00
4916-MSM4-P1-100UG
About this Product
- SKU:
- 4916-MSM4-P1
- Additional Names:
- GP145-TrkC | Neurotrophic tyrosine kinase receptor type 3 | TrkC tyrosine kinase
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- NTRK3/8796
- Clonality:
- Monoclonal
- Extra Details:
- The Trk proto-oncogene encodes a tyrosine protein kinase; Trk A; also designated Trk gp140; that serves as a receptor for certain neurotrophic factors including nerve growth factor (NGF) and neurotrophin-3 (NT-3). Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3; but not NGF; can induce rapid phosphorylation on tyrosine of Trk B gp145; one of the receptors encoded by Trk B; although BDNF elicits a response at least two orders of magnitude greater than NT-3. Thus it appears that Trk B gp145 may represent a neurotrophic receptor for BDNF and NT-3. The third member of the Trk family of tyrosine kinases; Trk C; is mainly expressed in nervous tissue; and is a functional receptor for NT-3. Four forms of Trk C are produced by alternative splicing. Isoform A is full length Trk C; isoform B differs from A between amino acids 529 to 612 and is missing amino acids 613 to 839. Trk C; isoform C is missing amino acids 712 to 725 and isoform D is missing amino acids 402 to 410.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa100-300) of human NTRK3 protein (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 50-145kDa
- Research Area:
- AKT Signaling; Cardiovascular; Neuroscience; Nuclear Marker; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=145759
