NTRK2 (Neurotrophic Receptor Tyrosine Kinase 2) Antibody
Product Sizes
100 ug
£671.00
4915-MSM9-P1ABX-100UG
About this Product
- SKU:
- 4915-MSM9-P1ABX
- Additional Names:
- GP145-TrkB | Neurotrophic tyrosine kinase receptor type 2 | TrkB tyrosine kinase | Tropomyosin-related kinase B
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- NTRK2/7929
- Clonality:
- Monoclonal
- Extra Details:
- The Trk proto-oncogene encodes a tyrosine protein kinase; Trk A; also designated Trk gp140; that serves as a receptor for certain neurotrophic factors including nerve growth factor (NGF) and neurotrophin-3 (NT-3). Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3; but not NGF; can induce rapid phosphorylation on tyrosine of Trk B gp145; one of the receptors encoded by NTRK2; although BDNF elicits a response at least two orders of magnitude greater than NT-3. Thus it appears that Trk B gp145 may represent a neurotrophic receptor for BDNF and NT-3. The third member of the Trk family of tyrosine kinases; Trk C; encodes a protein designated Trk C gp145 that is preferentially expressed in brain tissue; is equally related to Trk A and Trk B and is a functional receptor for NT-3.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa250-450) of human NTRK2 protein (exact sequence is proprietary)
- Isotype:
- IgG2c
- Molecular Weight:
- 95-145kDa
- Research Area:
- Neuroscience; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=135920
