CD73 (Immuno-Oncology Target) Antibody
Product Sizes
100 ug
£671.00
4907-MSM9-P1-100UG
About this Product
- SKU:
- 4907-MSM9-P1
- Additional Names:
- 5'-deoxynucleotidase | Ecto-5'-nucleotidase | IMP-specific 5'-nucleotidase | Thymidylate 5'-phosphatase
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- NT5E/4679
- Clonality:
- Monoclonal
- Extra Details:
- CD73 is a membrane-bound extracellular enzyme overexpressed in several cancer types. Its expression has been linked to poor prognosis in melanoma; colorectal; gastric; triple negative breast cancer; and to a pro-metastatic phenotype in prostate cancer. Together with CD39; it plays a major role in promoting immunosuppression through the pathway degrading adenosine triphosphate (ATP) into adenosine. Within the tumor microenvironment; ATP promotes immune cell-mediated killing of cancer cells. In contrast; adenosine accumulation causes immune suppression; dysregulation of immune cell infiltrates and stimulates angiogenesis resulting in tumor spreading. CD73 is active on the last step of the degradation pathway; where it is the enzyme that actually degrades AMP into adenosine. CD73-blockade promotes anti-tumor immunity by reducing adenosine accumulation. Accordingly; anti-CD73 mAbs stimulate anti-tumor immunity and reduce tumor metastasis in mouse tumor models; and could enhance the efficacy of treatment with anti-PD1 or anti-CTLA4 antibodies.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human NT5E protein
- Isotype:
- IgG1
- Molecular Weight:
- 71kDa
- Research Area:
- B Cell Markers; Immune checkpoint; Infectious Disease; Neuroscience
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=130970
