CD73 (Immuno-Oncology Target) Antibody
Product Sizes
100 ug
£671.00
4907-MSM1-P1-100UG
About this Product
- SKU:
- 4907-MSM1-P1
- Additional Names:
- Ecto-5'-nucleotidase
- Application:
- Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- NT5E/2503
- Clonality:
- Monoclonal
- Extra Details:
- CD73 (also designated ecto-5'-nucleotidase; E5NT; NT; NT5; NTE; eN and eNT) is a glycosyl-phosphatidylinositol (GPI)-anchored adhesion protein that catalyzes the dephosphorylation of extracellular purine and pyrimidine nucleotides to their corresponding bioactive nucleosides. CD73 is a dimer of two identical subunits that depends on GPI to link with the external face of the plasma membrane. Similar to other GPI-anchored proteins; CD73 mediates co-stimulatory signals in T cell activation. CD73 has few structural variants; yet elicits diverse biological function through differential regulation in endothelial cells (EC); subpopulations of B and T cells; germinal center follicular dendritic cells and on thymic medullary reticular fibroblasts. For example; IgG mediated neutralization of CD73 interferes with lymphocyte adhesion to EC; and blocks aggregation of germinal center B cells and follicular dendritic cells. Furthermore; IgG-mediated targeting of lymphocyte CD73; but not of endothelial cell CD73; causes shedding of CD73 and tyrosine phosphorylation of proteins.
- Host:
- Mouse
- Immunogen:
- Recombinant full length human NT5E protein
- Isotype:
- IgG1
- Molecular Weight:
- 71kDa
- Research Area:
- B Cell Markers; Immune checkpoint; Infectious Disease; Neuroscience
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=118954
