Recombinant Nucleophosmin (Acute Myeloid Leukemia Marker) Antibody
Product Sizes
100 ug
£671.00
4869-MSM14-P1-100UG
About this Product
- SKU:
- 4869-MSM14-P1
- Additional Names:
- Nucleolar phosphoprotein B23 | Nucleolar protein NO38 | Numatrin
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- rNPM1/8056
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a 33kDa glycoprotein; identified as Nucleophosmin (NPM). It is predominantly localized in the nucleus of cells in most tissues. NPM is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis. This phosphoprotein moves between the nucleus and the cytoplasm. It is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners; in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location. Mutations in this gene are associated with acute myeloid leukemia. ÔøΩThe antibody may be a useful aid for classification of acute myeloid leukemia.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human NPM1 protein (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 33kDa
- Research Area:
- Infectious Disease; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=130969
