NKX6.1 (Marker for Pancreatic and Duodenal Neuroendocrine Tumors) Antibody
Product Sizes
100 ug
£671.00
4825-MSM1-P1ABX-100UG
About this Product
- SKU:
- 4825-MSM1-P1ABX
- Additional Names:
- Homeobox protein NK-6 homolog A
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- NKX61/2561
- Clonality:
- Monoclonal
- Extra Details:
- Members of the Nkx family of homeodomain proteins are key regulators of growth and development in several tissues; including brain; heart and pancreas. During neural development; sonic hedgehog (Shh) is known to control cell fate and mitogenesis; which is correlated with Shh dose-dependent expression of several genes; including Nkx-6.1. Specifically; Nkx-6.1 is responsible for cellular differentiation in the ventral neural tube and spinal meninges in response to Shh. In the pancreas; Nkx-6.1 is exclusively expressed in the islets of Langerhans in differentiating and mature B cells; which produce Insulin. The presence of Pdx-1 is required for the expression of Nkx-6.1 as well as other pancreatic B cell specific genes; including Insulin; Glut2 and IAPP. Subsequently; Nkx-6.1 binds to the DNA consensus sequence; TTAATTAC; to direct the repression of specific genes in B cells. Nkx6.1 is highly expressed in pancreatic and duodenal well-differentiated neuroendocrine tumors (WDNETS) and in metastatic WDNETS; is a highly specific marker of tumors of pancreatic origin. It has thus been suggested that Nkx6.1 is a useful inclusion into IHC panels for identifying primary sites of WDNETS.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human NKX6.1 protein
- Isotype:
- IgG2c
- Molecular Weight:
- 40-50kDa
- Research Area:
- Autophagy; Developmental Biology; Nuclear Marker; Stem Cell Differentiation
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=118891
