Recombinant MyoD1 (Rhabdomyosarcoma Marker) Antibody
Product Sizes
20 ug
£364.00
4654-RBM8-P0-20UG
About this Product
- SKU:
- 4654-RBM8-P0
- Additional Names:
- Class C basic helix-loop-helix protein 1 | Myogenic factor 3
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- MYOD1/3418R
- Clonality:
- Monoclonal
- Extra Details:
- MyoD1; one of the MyoD family of myogenic helix-loop-helix transcription factors; combined with myogenin; plays a role in coordinating the myogenic differentiation pathway from the determination of mesodermal precursors into myoblasts; the differentiation of myoblasts into myotubes; and finally the maturation of myotubes into skeletal myofibers. Normal mature skeletal muscle does not express MyoD1 protein. MyoD1 is expressed in myoblasts before differentiation while myogenin has post-differentiation functions. Anti-MyoD1 immunostaining identifies cells committed to myogenesis in their earliest phase; thus; it is a better biomarker for less differentiated Rhabdomyosarcomas (RMS). RMS are the most frequent malignant soft tissue neoplasms of childhood. While better differentiated RMS have cross-striations or rhabdomyoblasts that allow for a confident morphologic diagnosis; less differentiated RMS resemble other small blue round-cell tumors. Studies suggest; anti-MyoD1 may be used together with anti-Myogenin and anti-Desmin as a panel of markers since any RMS is virtually never negative for all three markers simultaneously.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa1-100) of human MyoD1 protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 45kDa
- Research Area:
- Cardiovascular; Developmental Biology; Mesenchymal Stem Cell Differentiation; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=118626
