MXI1 Antibody
Product Sizes
100 ug
£671.00
4601-MSM1-P1ABX-100UG
About this Product
- SKU:
- 4601-MSM1-P1ABX
- Additional Names:
- Class C basic helix-loop-helix protein 11
- Application:
- Flow Cytometry, Immunofluorescence, Western Blot
- translate.label.attr.clone:
- PCRP-MXI1-1A3
- Clonality:
- Monoclonal
- Extra Details:
- It is now well established that Myc regulation of cell proliferation and differentiation involves a family of related transcription factors. One such factor; Max; is an obligate heterodimeric partner for Myc and can also form heterodimers with at least four related proteins designated Mad 1; Mxi1 (also designated Mad 2); Mad 3 and Mad 4. Like Mad 1 and Mxi1; association of Mad 3 and Mad 4 with Max results in transcriptional repression. Both Myc and the Mad proteins have short half-lives and their synthesis is tightly regulated; while Max expression is constitutive and relatively stable. Two related mammalian cDNAs have been identified and shown to encode Mad- binding proteins. Both possess sequence homology with the yeast transcription repressor Sin3 including four conserved paired amphipathic helix (PAH) domains. mSin3A and mSin3B specifically interact with the Mad proteins via their second paired amphipathic helix domain (PAH2). It has been suggested that Mad-Max heterodimers repress transcription by tethering mSin3 to DNA as corepressors.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human MXI1 protein
- Isotype:
- IgG2b
- Molecular Weight:
- 26/22/33/21 kDa (isoforms)
- Research Area:
- Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=118530
