MX1 / MX dynamin like GTPase 1 Antibody
Product Sizes
20 ug
£364.00
4599-MSM2-P0-20UG
About this Product
- SKU:
- 4599-MSM2-P0
- Additional Names:
- Interferon-induced protein p78 | Interferon-regulated resistance GTP-binding protein MxA | Myxoma resistance protein 1 | Myxovirus resistance protein 1
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- MX1/7527
- Clonality:
- Monoclonal
- Extra Details:
- The Dynamin family of microtubule-associated proteins function as GTPases that are involved in microtubule bundling and endocytosis. In mice; Mx2 (myxovirus resistance protein 2) and Mx1 (myxovirus resistance protein 1) are members of the Dynamin family that are involved in the immune response to viral infections. Localized to the cytoplasm; Mx2 contains one GED domain and is expressed in response to viral infection or treatment by IFN-a/IFN-b. Once expression is induced; Mx2 accumulates in the cytoplasm and inhibits the replication of vesicular stomatitis virus (VSV); thereby conferring resistance to VSV infection. Unlike Mx2; Mx1 is localized to the nucleus where; upon induction by IFN-a/IFN-b; it provides selective resistance to infection by the highly lethal H5N1 influenza virus. In humans; MxA and MxB function in a similar manner to Mx1 and Mx2; conferring resistance to specific target viruses. Mx3 is a rat-specific member of the myxovirus resistance protein family.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa400-592) of human MX1 protein (exact sequence is proprietary)
- Isotype:
- IgG2
- Molecular Weight:
- 72kDa
- Research Area:
- Cytokine Signaling; Immunology; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=130840
