Recombinant MUC5AC (Mucin 5AC / Gastric Mucin) Antibody
Product Sizes
20 ug
£364.00
4586-MSM24-P0-20UG
About this Product
- SKU:
- 4586-MSM24-P0
- Additional Names:
- Gastric mucin | Major airway glycoprotein | Mucin-5 subtype AC; tracheobronchial | Tracheobronchial mucin
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- MSVA-109M
- Clonality:
- Monoclonal
- Extra Details:
- Mucins are a group of high molecular weight glycoproteins consisting of a mucin core protein and O-linked carbohydrates. Mucin 6 carries GlcNAcα1→4Galβ→R structures; indicating that α1; 4-N-acetylglucosaminyltransferase is important to the formation of the mucous glycoproteins in vivo. Mucin 5AC is a gel-forming mucin that is secreted from surface mucous cells. Glucocorticoid is required for the expression of Mucin 5AC mRNA and high doses of hydrocortisone suppresses its expression. Additionally; asthmatic fluid stimulates Mucin 5AC synthesis several-fold. The pro-inflammatory cytokines IL-6 and TNFα stimulate Mucin 5AC secretion and thus contribute to the upregulation of mucin by chronic inflammation. Expression of Mucin 5AC is retinoic acid (RA)- or retinol-dependent; and RA control of mucin genes is mediated by the retinoid acid receptor RARα and; to a lesser extent; by RARγ. Thyroid hormone binding to thyroid receptors inhibits Mucin 5AC gene expression. Mucin 5AC is also expressed in normal endocervical epithelium; small intestine; gastric cells (Lewis type 1) and gastric metaplasia and it is one of the major mucins in the ethmoid mucosa.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human MUC5AC protein
- Isotype:
- IgG1
- Molecular Weight:
- 400-600 kDa
- Research Area:
- Cardiovascular; Immunology; Infectious Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=147529
