Recombinant MUC1 / CA15-3 / EMA / CD227 (Epithelial Marker) Antibody
Product Sizes
20 ug
£364.00
4582-MSM25-P0-20UG
About this Product
- SKU:
- 4582-MSM25-P0
- Additional Names:
- Breast carcinoma-associated antigen DF3 | Cancer antigen 15-3 | Carcinoma-associated mucin | Episialin | H23AG | Krebs von den Lungen-6 | PEMT | Peanut-reactive urinary mucin | Polymorphic epithelial mucin | Tumor-associated epithelial membrane antigen | Tumor-associated mucin
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- rMUC1/955
- Clonality:
- Monoclonal
- Extra Details:
- This MAb reacts with MUC1. The dominant epitope of this MAb has not yet been determined. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium; including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and over expressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four c-erbB receptors and localize with c-erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human MUC1 protein
- Isotype:
- IgG1
- Molecular Weight:
- 265-400kDa
- Research Area:
- Cytokine Signaling; Immunology; Infectious Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=118323
